BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:CDT SEMINAR- Dr. Wei Li\, Distinguished Professor at the Unive
 rsity of Tennessee Health Science Center College of Pharmacy (UTCoP). He i
 s also the Director of the Drug Discovery Center\, Co-Leader of the Chemic
 al Biology Program at the UTHSC Cancer Center\, 
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260912T162138Z
UID:tag:localist.com\,2008:EventInstance_51346781848836
DTSTART:20251203T200000Z
DTEND:20251203T210000Z
DESCRIPTION:Dr. Wei Li\n\nTitle: "The discoveries of brain penetrable tubul
 in inhibitors for breast cancer brain metastasis and selective TRPC3 inhib
 itors for epilepsy"\n\n \n\nShort summary of the presentation:\n\nBreast c
 ancer brain metastasis (BCBM) remains a clinical challenge marked by limit
 ed therapeutic options and poor survival rates. We developed a set of colc
 hicine binding site inhibitors (CBSIs) targeting tubulin\, that show poten
 t preclinical efficacy against brain and extracranial metastases in BCBM m
 odels. These compounds efficiently cross the BBB with high brain/plasma ra
 tios\, extend overall survival and suppress the expansion of pre-establish
 ed brain lesions. In the second part of the talk\, I will discuss our rece
 nt efforts in developing selective transient receptor potential canonical 
 3 (TRPC3) inhibitors for epilepsy. Perturbation in the expression of TRPC3
  are associated with several pathophysiological conditions responsible for
  disorders of cardiovascular\, immune\, and central nervous systems. While
  there are several reported TRPC3 inhibitors\, most of them either have lo
 w inhibition potency or are not selective for TRPC3. Collaborating with bi
 ologists\, we discovered new sets of metabolically stable and low-toxic TR
 PC3 inhibitors with good brain penetrations. These compounds are being eva
 luated in epilepsy and potentially other diseases.
GEO:33.751029;-84.385581
LOCATION:Parker H. Petit Science Center\, PSC124
SUMMARY:CDT SEMINAR- Dr. Wei Li\, Distinguished Professor at the University
  of Tennessee Health Science Center College of Pharmacy (UTCoP). He is als
 o the Director of the Drug Discovery Center\, Co-Leader of the Chemical Bi
 ology Program at the UTHSC Cancer Center\, 
URL;VALUE=URI:https://calendar.gsu.edu/event/cdt-seminar-dr-wei-li-distingu
 ished-professor-at-the-university-of-tennessee-health-science-center-colle
 ge-of-pharmacy-utcop-he-is-also-the-director-of-the-drug-discovery-center-
 co-leader-of-the-chemical-biology-program-at-the-uthsc-cancer-
CATEGORIES:Lecture
END:VEVENT
END:VCALENDAR